2D4H2 is an ambitious project aimed to boost the market launch of renewable hydrogen electrolysers as one of the main instruments to achieve clean and secure energy systems. This will aim to be achieved through the development of a proof of concept (PoC) of an advanced Anion Exchange Membrane Water Electrolyser (AEMWE) stack as a critical milestone to translate the highly promising results coming from the ground-breaking research conducted during a previous ERC-StG into a marketable innovation. The AEMWE stack novelty relies on non-toxic CRM-free breakthrough novel electrodes (anodes) made of two-dimensional (2D) nickel-iron layered double hydroxide materials (2D NiFe-LDHs) that have shown during the ERC-StG an outstanding catalytic behaviour. Using this electrocatalytic material will allow overcoming the main challenges of WE to produce green H2.